I can’t seem to get excited about this. Apart from some rain squalls, it is over. There are bubbles in the bathtub but the water isn’t brown.
The most recent report from HVO says the lava feeding the outbreak tube is low. Until it re-energizes, the flow will have to wait. Apparently it depends on who you talk to.
I have coined the term OBOLA and I shall use it.
I am beginning to suspect that the ebola which showed up is not the same ebola everyone was expecting. I’m not going to go off on a rant (surprisingly enough) but sending 4,000+ military troops to Africa, only some of which are medical personnel, smells of fish – especially since they weren’t sent to the most highly affected areas. I suspect they were sent to try to clean up a US bioweapon experiment that got loose, and there are precedents, as my fellow researcher Yohanan discovered.
That “Beat it at it’s source in Africa” mantra makes no sense. If it is loose in the US, WE ARE THE SOURCE! The troops are in Africa for an entirely different reason.
People wishing to see for themselves instead of depending on a ten-second TV news talking head can research it here, beginning with some definitions of medical subjects you need to know before deciding how to proceed. Yohanan has already done the hard work for you.
46 MeSH Medical Subject Headings in SUMMARY (terse) MODE (in arbitrary search and not alphabetic order):
The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. The pathogenic capacity of an organism is determined by its VIRULENCE FACTORS.
Year introduced: 1966(1965)
2: pathogenicity [Subheading]:
Used with microorganisms, viruses, and parasites for studies of their ability to cause disease in man, animals, or plants.
Year introduced: 1966
3: Virulence Factors:
Those components of an organism that determine its capacity to cause disease but are not required for its viability per se. Two classes have been characterized: TOXINS, BIOLOGICAL and surface adhesion molecules that effect the ability of the microorganism to invade and colonize a host. (From Davis et al., Microbiology, 4th ed. p486) Year introduced: 2003
A genus in the family FILOVIRIDAE consisting of several distinct species of Ebolavirus, each containing separate strains. These viruses cause outbreaks of a contagious, hemorrhagic disease (HEMORRHAGIC FEVER, EBOLA) in humans, usually with high mortality.
Year introduced: 2007 (2002)
5: Genomic Islands:
Distinct units in some bacterial, bacteriophage or plasmid GENOMES that are types of MOBILE GENETIC ELEMENTS. Encoded in them are a variety of fitness conferring genes, such as VIRULENCE FACTORS (in “pathogenicity islands or islets”), ANTIBIOTIC RESISTANCE genes, or genes required for SYMBIOSIS (in “symbiosis islands or islets”). They range in size from 10 – 500 kilobases, and their GC CONTENT and CODON usage differ from the rest of the genome. They typically contain an INTEGRASE gene, although in some cases this gene has been deleted resulting in “anchored genomic islands”.
Year introduced: 2004
6: Infectious Disease Transmission, Patient-to-Professional:
The transmission of infectious disease or pathogens from patients to health professionals or health care workers. It includes transmission via direct or indirect exposure to bacterial, fungal, parasitic, or viral agents.
Year introduced: 2009 (1994)
7: Infectious Disease Transmission, Professional-to-Patient:
The transmission of infectious disease or pathogens from health professional or health care worker to patients. It includes transmission via direct or indirect exposure to bacterial, fungal, parasitic, or viral agents.
Year introduced: 2009 (1994)
8: Hand Sanitizers:
Preparations used as alternatives or supplements to hand washing with soap and water to destroy microorganisms and prevent transmission of pathogens. The active ingredient may be ETHANOL; 1-PROPANOL; or POVIDONE-IODINE in a gel, foam, or liquid solution.
Year introduced: 2014
9: Disease Resistance:
The capacity of an organism to defend itself against pathological processes or the agents of those processes. This most often involves innate immunity whereby the organism responds to pathogens in a generic way. The term disease resistance is used most frequently when referring to plants.
Year introduced: 2012
10: Infectious Disease Transmission, Vertical:
The transmission of infectious disease or pathogens from one generation to another. It includes transmission in utero or intrapartum by exposure to blood and secretions, and postpartum exposure via breastfeeding.
Year introduced: 2009 (1995)
11: Disease Transmission, Infectious:
The transmission of infectious disease or pathogens. When transmission is within the same species, the mode can be horizontal or vertical (INFECTIOUS DISEASE TRANSMISSION, VERTICAL).
Year introduced: 2009 (1995)
12: Vaccines, Synthetic:
Small synthetic peptides that mimic surface antigens of pathogens and are immunogenic, or vaccines manufactured with the aid of recombinant DNA techniques.
The latter vaccines may also be whole viruses whose nucleic acids have been modified.
Year introduced: 1991(1987)
13: Medical Waste:
Blood, mucus, tissue removed at surgery or autopsy, soiled surgical dressings, and other materials requiring special disposal procedures.
Year introduced: 1991(1978)
14: Post-Exposure Prophylaxis:
The prevention of infection or disease following exposure to a pathogen.
Year introduced: 2010
15: Host Specificity:
The properties of a pathogen that makes it capable of infecting one or more specific hosts. The pathogen can include PARASITES as well as VIRUSES; BACTERIA; FUNGI; or PLANTS.
Year introduced: 2011
16: Ebola Vaccines:
Vaccines or candidate vaccines used to prevent EBOLA HEMORRHAGIC FEVER.
Year introduced: 2005
17: Hemorrhagic Fever, Ebola:
A highly fatal, acute hemorrhagic fever, clinically very similar to MARBURG VIRUS DISEASE, caused by EBOLAVIRUS, first occurring in the Sudan and adjacent northwestern (what was then) Zaire.
Year introduced: 1996
18: envelope glycoprotein, Ebola virus [Supplementary Concept]:
protects mice from lethal challenge; GP1 and GP2 are furin convertase cleavage products of fully glycosylated GP, known as GP0; GP1 is a surface subunit and GP2 is a transmembrane subunit; has been sequenced; GenBank U28077 Date introduced: July 24, 1998
19: secreted glycoprotein, Ebola virus [Supplementary Concept]:
secreted form of Ebola virus glycoprotein; secreted and transmembrane forms arise from RNA editing; amino acid sequence in first source Date introduced: March 3, 1998
20: transmembrane glycoprotein, Ebola virus [Supplementary Concept]:
produced during infection and incorporated into virion; interacts with endothelial cells; secreted and transmembrane forms arise from RNA editing; base sequence in first source Date introduced: March 3, 1998
21: nucleoprotein VP40, Ebola virus [Supplementary Concept]:
a major nucleoprotein product of third gene; amino acid sequence (third gene) given in first source Date introduced: January 12, 1994
22: VP30 protein, ebola virus [Supplementary Concept]:
has been sequenced Date introduced: December 24, 2003
23: VP24 protein, Ebola virus [Supplementary Concept]:
may have a role in virus assembly and budding; amino acid sequence in first source Date introduced: February 15, 2002
24: VP40 protein, virus [Supplementary Concept]:
amino acid sequences of Marburg and Ebola virus VP40 proteins given in first source Date introduced: May 27, 1993
25: nucleocapsid protein, Ebola virus [Supplementary Concept]:
protects mice from lethal challenge; has been sequenced; GenBank AF054908 Date introduced: July 24, 1998
26: VP35 protein, filovirus [Supplementary Concept]:
Blocks virus-induced phosphorylation and activation of interferon regulatory factor 3 Date introduced: May 27, 1993
27: nucleoprotein, Marburg virus [Supplementary Concept]:
has homology to Ebola virus; amino acid sequence given in first source Date introduced: March 25, 1992
The relating of causes to the effects they produce. Causes are termed necessary when they must always precede an effect and sufficient when they initiate or produce an effect. Any of several factors may be associated with the potential disease causation or outcome, including predisposing factors, enabling factors, precipitating factors, reinforcing factors, and risk factors.
Year introduced: 1990
Minute infectious agents whose genomes are composed of DNA or RNA, but not both. They are characterized by a lack of independent metabolism and the inability to replicate outside living host cells.
Year introduced: 1963
30: Antiviral Agents:
Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.
A family of RNA viruses, of the order MONONEGAVIRALES, containing filamentous virions. Although they resemble RHABDOVIRIDAE in possessing helical nucleocapsids, Filoviridae differ in the length and degree of branching in their virions. There are two genera: EBOLAVIRUS and MARBURGVIRUS.
Year introduced: 1992
Epidemics of infectious disease that have spread to many countries, often more than one continent, and usually affecting a large number of people.
Year introduced: 2011
33: Environmental Exposure:
The exposure to potentially harmful chemical, physical, or biological agents in the environment or to environmental factors that may include ionizing radiation, pathogenic organisms, or toxic chemicals.
Year introduced: 1974(1967)
34: Virus Latency:
The ability of a pathogenic virus to lie dormant within a cell (latent infection). In eukaryotes, subsequent activation and viral replication is thought to be caused by extracellular stimulation of cellular transcription factors. Latency in bacteriophage is maintained by the expression of virally encoded repressors.
Year introduced: 1994
35: Social Isolation:
The separation of individuals or groups resulting in the lack of or minimizing of social contact and/or communication. This separation may be accomplished by physical separation, by social barriers and by psychological mechanisms. In the latter, there may be interaction but no real communication.
Year introduced: 1969
36: Hospitals, Isolation:
Hospitals designed or used to isolate or quarantine persons with communicable diseases.
Year introduced: 2009
37: Patient Isolation:
The segregation of patients with communicable or other diseases for a specified time. Isolation may be strict, in which movement and social contacts are limited; modified, where an effort to control specified aspects of care is made in order to prevent cross infection; or reverse, where the patient is secluded in a controlled or germ-free environment in order to protect him or her from cross infection.
Year introduced: 1977
Restriction of freedom of movement of individuals who have been exposed to infectious or communicable disease in order to prevent its spread; a period of detention of vessels, vehicles, or travelers coming from infected or suspected places; and detention or isolation on account of suspected contagion. It includes government regulations on the detention of animals at frontiers or ports of entrance for the prevention of infectious disease, through a period of isolation before being allowed to enter a country. (From Dorland, 28th ed and Black’s Veterinary Dictionary, 17th ed)
Continuance of life or existence especially under adverse conditions; includes methods and philosophy of survival.
40: Hemorrhagic Fevers, Viral:
A group of viral diseases of diverse etiology but having many similar clinical characteristics; increased capillary permeability, leukopenia, and thrombocytopenia are common to all. Hemorrhagic fevers are characterized by sudden onset, fever, headache, generalized myalgia, backache, conjunctivitis, and severe prostration, followed by various hemorrhagic symptoms. Hemorrhagic fever with kidney involvement is HEMORRHAGIC FEVER WITH RENAL SYNDROME.
Year introduced: 1978
41: Health Care Rationing:
Planning for the equitable allocation, apportionment, or distribution of available health resources.
Year introduced: 1989
42: Health Services Accessibility:
The degree to which individuals are inhibited or facilitated in their ability to gain entry to and to receive care and services from the health care system. Factors influencing this ability include geographic, architectural, transportational, and financial considerations, among others.
Year introduced: 1978
43: Disaster Planning:
Procedures outlined for the care of casualties and the maintenance of services in disasters.
Year introduced: 1978
44: Disaster Medicine:
Branch of medicine involved with management and organization of public health response to disasters and major events including the special health and medical needs of a community in a disaster.
Year introduced: 2008
Calamities producing great damage, loss of life, and distress. They include results of natural phenomena and man-made phenomena. Normal conditions of existence are disrupted and the level of impact exceeds the capacity of the hazard-affected community.
46: Extinction, Biological:
The ceasing of existence of a species or taxonomic groups of organisms.
Year introduced: 2007
|1.||Surveillance and Preparedness for Ebola Virus Disease – New York City, 2014.|
|Benowitz I, Ackelsberg J, Balter SE, Baumgartner JC, Dentinger C, Fine AD, Harper SA, Jones LE, Laraque F, Lee EH, Merizalde G, Yacisin KA, Varma JK, Layton MC.|
|MMWR Morb Mortal Wkly Rep. 2014 Oct 17;63(41):934-936.|
|PMID: 25321072 [PubMed – as supplied by publisher]|
|2.||Transmission dynamics and control of Ebola virus disease (EVD): a review.|
|Chowell G, Nishiura H.|
|BMC Med. 2014 Oct 10;12(1):196. [Epub ahead of print]|
|PMID: 25300956 [PubMed – as supplied by publisher] Free Article|
|3.||Triage: Care of the Critically Ill and Injured During Pandemics and Disasters: CHEST Consensus Statement.|
|Christian MD, Sprung CL, King MA, Dichter JR, Kissoon N, Devereaux AV, Gomersall CD; Task Force for Mass Critical Care; Task Force for Mass Critical Care.|
|Chest. 2014 Oct 1;146(4 Suppl):e61S-74S. doi: 10.1378/chest.14-0736.|
|PMID: 25144591 [PubMed – in process]|
|4.||Ebola virus disease–current knowledge.|
|N Engl J Med. 2014 Sep 25;371(13):e18. doi: 10.1056/NEJMp1410741. No abstract available.|
|PMID: 25251632 [PubMed – indexed for MEDLINE] Free Article|
|5.||The 1899-1900 plague epidemic in Hawaii, USA.|
|Asia Pac J Public Health. 2014 Jan;26(1):7-14. doi: 10.1177/1010539513519365. No abstract available.|
|PMID: 24418999 [PubMed – indexed for MEDLINE]|
|6.||Insights in public health: systems thinking: basic constructs, application challenges, misuse in health, and how public health leaders can pave the way forward.|
|Hawaii J Med Public Health. 2013 Dec;72(12):440-4.|
|PMID: 24377080 [PubMed – in process] Free PMC Article|
|7.||Disasters, catastrophes, and worse: a scalar taxonomy.|
|Camb Q Healthc Ethics. 2013 Jul;22(3):297-307. doi: 10.1017/S096318011300011X. Epub 2013 Apr 30. No abstract available.|
|PMID: 23631860 [PubMed – indexed for MEDLINE]|
|8.||Pathology of experimental aerosol Zaire ebolavirus infection in rhesus macaques.|
|Twenhafel NA, Mattix ME, Johnson JC, Robinson CG, Pratt WD, Cashman KA, Wahl-Jensen V, Terry C, Olinger GG, Hensley LE, Honko AN.|
|Vet Pathol. 2013 May;50(3):514-29. doi: 10.1177/0300985812469636. Epub 2012 Dec 23.|
|PMID: 23262834 [PubMed – indexed for MEDLINE] Free Article|
|9.||Viral haemorrhagic fevers in healthcare settings.|
|Ftika L, Maltezou HC.|
|J Hosp Infect. 2013 Mar;83(3):185-92. doi: 10.1016/j.jhin.2012.10.013. Epub 2013 Jan 16. Review.|
|PMID: 23333147 [PubMed – indexed for MEDLINE]|
|10.||Ethics of clinical science in a public health emergency: drug discovery at the bedside.|
|Am J Bioeth. 2013;13(9):3-14. doi: 10.1080/15265161.2013.813597.|
|PMID: 23952822 [PubMed – indexed for MEDLINE] Free PMC Article|
|11.||Review of Ebola virus infections in domestic animals.|
|Weingartl HM, Nfon C, Kobinger G.|
|Dev Biol (Basel). 2013;135:211-8. doi: 10.1159/000178495. Epub 2013 May 14. Review.|
|PMID: 23689899 [PubMed – indexed for MEDLINE]|
|12.||Use of the Syrian hamster as a new model of ebola virus disease and other viral hemorrhagic fevers.|
|Wahl-Jensen V, Bollinger L, Safronetz D, de Kok-Mercado F, Scott DP, Ebihara H.|
|Viruses. 2012 Dec 14;4(12):3754-84. doi: 10.3390/v4123754. Review.|
|PMID: 23242370 [PubMed – indexed for MEDLINE] Free PMC Article|
|13.||Development of a murine model for aerosolized ebolavirus infection using a panel of recombinant inbred mice.|
|Zumbrun EE, Abdeltawab NF, Bloomfield HA, Chance TB, Nichols DK, Harrison PE, Kotb M, Nalca A.|
|Viruses. 2012 Dec 3;4(12):3468-93. doi: 10.3390/v4123468. Review.|
|PMID: 23207275 [PubMed – indexed for MEDLINE] Free PMC Article|
|14.||Guidance for contact tracing of cases of Lassa fever, Ebola or Marburg haemorrhagic fever on an airplane: results of a European expert consultation.|
|Gilsdorf A, Morgan D, Leitmeyer K.|
|BMC Public Health. 2012 Nov 21;12:1014. doi: 10.1186/1471-2458-12-1014. Review.|
|PMID: 23170851 [PubMed – indexed for MEDLINE] Free PMC Article|
|15.||Epidemiological isolation causing variable mortality in Island populations during the 1918-1920 influenza pandemic.|
|Shanks GD, Hussell T, Brundage JF.|
|Influenza Other Respir Viruses. 2012 Nov;6(6):417-23. doi: 10.1111/j.1750-2659.2011.00332.x. Epub 2012 Jan 6.|
|PMID: 22226378 [PubMed – indexed for MEDLINE]|
|16.||On case-fatality rate: review and hypothesis.|
|Jpn J Infect Dis. 2012 Jul;65(4):279-88. Review.|
|PMID: 22814148 [PubMed – indexed for MEDLINE] Free Article|
|17.||Pediatric mass critical care in a pandemic.|
|Pediatr Crit Care Med. 2012 Jan;13(1):e1-4. doi: 10.1097/PCC.0b013e3181fe390a.|
|PMID: 21037504 [PubMed – indexed for MEDLINE]|
|18.||Transmission of Ebola virus from pigs to non-human primates.|
|Weingartl HM, Embury-Hyatt C, Nfon C, Leung A, Smith G, Kobinger G.|
|Sci Rep. 2012;2:811. doi: 10.1038/srep00811. Epub 2012 Nov 15.|
|PMID: 23155478 [PubMed – indexed for MEDLINE] Free PMC Article|
|19.||Mass extinctions, biodiversity and mitochondrial function: are bats ‘special’ as reservoirs for emerging viruses?|
|Wang LF, Walker PJ, Poon LL.|
|Curr Opin Virol. 2011 Dec;1(6):649-57. doi: 10.1016/j.coviro.2011.10.013. Epub 2011 Nov 9. Review.|
|PMID: 22440923 [PubMed – indexed for MEDLINE]|
|20.||Aerosol exposure to Zaire ebolavirus in three nonhuman primate species: differences in disease course and clinical pathology.|
|Reed DS, Lackemeyer MG, Garza NL, Sullivan LJ, Nichols DK.|
|Microbes Infect. 2011 Oct;13(11):930-6. doi: 10.1016/j.micinf.2011.05.002. Epub 2011 May 25.|
|PMID: 21651988 [PubMed – indexed for MEDLINE]|
|21.||Why do influenza virus subtypes die out? A hypothesis.|
|Palese P, Wang TT.|
|MBio. 2011 Aug 30;2(5). pii: e00150-11. doi: 10.1128/mBio.00150-11. Print 2011. Review.|
|PMID: 21878571 [PubMed – indexed for MEDLINE] Free PMC Article|
|22.||Preparing for an influenza pandemic: are some people more equal than others?|
|Rosoff PM, DeCamp M.|
|J Health Care Poor Underserved. 2011 Aug;22(3 Suppl):19-35. doi: 10.1353/hpu.2011.0098.|
|PMID: 21857134 [PubMed – indexed for MEDLINE]|
|23.||Imagining the unthinkable, illuminating the present.|
|J Clin Ethics. 2011 Spring;22(1):17-9.|
|PMID: 21595350 [PubMed – indexed for MEDLINE]|
|24.||Enhancing the fairness of pandemic critical care triage.|
|J Med Ethics. 2010 Dec;36(12):758-61. doi: 10.1136/jme.2010.035501. Epub 2010 Oct 12.|
|PMID: 20940175 [PubMed – indexed for MEDLINE]|
|25.||Pandemic preparedness in Hawaii: a multicenter verification of real-time RT-PCR for the direct detection of influenza virus types A and B.|
|Whelen AC, Bankowski MJ, Furuya G, Honda S, Ueki R, Chan A, Higa K, Kumashiro D, Moore N, Lee R, Koyamatsu T, Effler PV.|
|Public Health Rep. 2010 May-Jun;125 Suppl 2:81-7.|
|PMID: 20518448 [PubMed – indexed for MEDLINE] Free PMC Article|
|26.||Worst case: rethinking tertiary triage protocols in pandemics and other health emergencies.|
|Crit Care. 2010;14(1):103. doi: 10.1186/cc8216. Epub 2010 Jan 21.|
|PMID: 20122291 [PubMed – indexed for MEDLINE] Free PMC Article|
|27.||Conservation. Scientists say Ebola has pushed western gorillas to the brink.|
|Science. 2007 Sep 14;317(5844):1484. No abstract available.|
|PMID: 17872416 [PubMed – indexed for MEDLINE]|